i really need to know the answer to this?
Thiamin (vitamin B1) is a significant cofactor in one of his reactions in the Krebs cycle, and the Reaction that converts pyruvate to CoA acetly (transition reaction). It is usually in the diet in yeast, found pork, legumes, cereals and Rice. It may be malnutrition or deficient conditions such as alcoholism, anorexia, and HIV. How will that effect cellular respiration? How could our bodies compensate for that? How successful do you think will be our body?
If you are deficient in thiamin, you will be able to make less energy through cellular respiration, so that with Fermentation to compensate, thus lactate, where you will be sour, and acetoacetate with the creation of ketone bodies (, hydroxybutyrate) from fat. There is a variety of problems be. For example produces the urea cycle, fumarate, which is normally metabolized in the Krebs cycle. If the concentration of fumarate increased the production of urea is impaired, the degradation of amino acids, further increases in plasma amino acid and leaves uncatabolized acids affect the plasma, increasing osmotic pressure and fluid retention. A set of molecules are broken down to metabolites of the Krebs cycle, the impairment of the Krebs cycle interferes with all kind of physiological processes. m